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Calcium channel blockers and digoxin lanoxin can lower blood pressure and heart rate to dangerous levels when administered together with metoprolol.

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In the dig trial a trial investigating the effect of digoxin on mortality and morbidity in patients with heart failure , the incidence of hospitalization for suspected digoxin toxicity was 2 in patients taking lanoxin compared to 0.

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Lanoxin tablets are supplied as 125 or 250 mcg microgram once a day; adequate dosing without toxicity is determined usually by a blood test that determines the drug s level in the blood.

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